Biostimulator Injections
Supporting your skin's natural regeneration over time
Biostimulator injections work with your skin's biology to support its regeneration, quality and density. Over time, the skin naturally produces less collagen and elastin, the support fibers that give it firmness and bounce; rather than adding immediate volume, biostimulators reactivate these processes, with an effect that builds gradually over weeks to months. Depending on the treatment, this can involve stimulating collagen, delivering growth factors from your own blood, or supporting deep hydration. Every biostimulator treatment at Dermapure begins with a personalized consultation with our medical team to assess whether this approach is right for you and to discuss your goals, the expected outcome and the possible side effects.
Collagen Stimulators
Collagen stimulators are injectable treatments that prompt your body to produce its own collagen at the treatment site. Collagen is the skin's main structural protein: these treatments stimulate the fibroblasts, the dermal cells that make it, so the skin rebuilds its own support. The result builds gradually, supporting facial volume, contour and skin quality with a progressive, longer-lasting effect.
Explore our collagen-stimulating treatments
Poly-L-Lactic Acid Injections
Poly-L-lactic acid (PLLA) injections gradually stimulate collagen production at the injection site. The particles act as a repair signal: the skin activates its fibroblasts, which lay down a new collagen network around them before they are absorbed. The result therefore builds at the pace of natural collagen formation, supporting facial volume and skin firmness over several months.
Calcium Hydroxylapatite Injections
Calcium hydroxylapatite (CaHA) injections have a dual action: immediate structural support from the microspheres, and progressive collagen stimulation. The microspheres act as a temporary scaffold onto which fibroblasts deposit new collagen; as the gel is absorbed, this newly formed collagen takes over the support. The treatment can support facial contours, jawline definition and skin quality.
Thread Face Lift
Thread face lift uses bioresorbable threads placed beneath the skin to provide subtle lifting and to stimulate collagen along their path. This controlled micro-stimulation acts as a repair signal that encourages fibroblasts to form new collagen. The threads dissolve gradually as this collagen develops, supporting facial structure and skin firmness over time.
Skin Quality Boosters
Skin quality boosters deliver hyaluronic acid and complementary ingredients across a broad area of the skin. Hyaluronic acid is a molecule naturally present in the skin that can hold a large amount of water: spread widely through the tissues, it supports hydration from within rather than at the surface. Unlike fillers that focus on volume, these treatments work on the overall condition of the skin, with effects that develop over a series of sessions.
Explore our Skin Quality Boosters
Skin Booster
Skin boosters use specialized hyaluronic acid formulations designed for broad delivery across the skin rather than localized volume. Spread evenly, this hydration supports deep hydration, suppleness and skin texture, and can encourage mild renewal activity, over a series of sessions. Several formulations are available and selected based on your skin condition and goals.
Mesotherapy
Mesotherapy delivers a customized blend of vitamins, antioxidants, hyaluronic acid and other ingredients through a series of small injections into the mesoderm, the middle layer of the skin. The technique supports hydration, glow and overall skin quality, with the blend tailored to your skin needs.
Platelet-Rich Plasma (PRP)
Platelet-Rich Plasma (PRP) uses a small sample of your own blood, processed to concentrate the platelets and their growth factors, natural messengers that signal skin cells to repair and renew. The concentrate is then reintroduced into the targeted area, where it amplifies the repair signals your body already uses naturally. As an autologous treatment, PRP works only with materials from your own body.
Explore our PRP treatments
PRP Facial
PRP facial treatments deliver your own platelet-rich plasma into the skin of the face to support natural regeneration, skin quality and texture. The treatment is often delivered through microinjections, microneedling-assisted application or other targeted methods, depending on the treatment plan.
PRP Dark Circles
Dark under-eye circles can result from thin skin, shadowing or pigmentation in the delicate eye area. PRP treatments for the under-eye area use your own platelet-rich plasma to support skin quality and tone in this zone, with placement adapted to the delicate anatomy around the eyes. By supporting the quality and thickness of this particularly thin skin, the treatment aims to soften the dull or hollow appearance linked to its thinness.
PRP Hair Loss
PRP for hair loss uses your own platelet-rich plasma delivered to the scalp through microinjections, microneedling-assisted application or other targeted delivery methods, to support the hair follicles and natural hair growth. The treatment is generally delivered as a series of sessions, with a plan personalized to your scalp condition and goals.
P-Shot Injection
The P-Shot is an in-clinic option for men exploring a non-surgical approach to the intimate area using their own platelet-rich plasma. The technique is personalized to individual anatomy and discussed in detail with our medical team during consultation.
O-Shot Injection
The O-Shot is an in-clinic option for women exploring a non-surgical approach using their own platelet-rich plasma to support tissue quality in the intimate area. The technique is personalized and discussed in detail with our medical team during consultation.
Platelet-Rich Fibrin (PRF)
Platelet-Rich Fibrin (PRF) is a next-generation evolution of PRP. Fibrin, a protein naturally involved in healing, forms a scaffold that traps the platelets and releases their growth factors slowly, over several days rather than all at once. This prolonged release is what sets PRF apart from PRP and supports tissue renewal over time.
PRF Treatment
PRF treatment uses your own platelet-rich fibrin to support skin regeneration, quality and texture. The fibrin matrix releases growth factors progressively over time, contributing to a sustained renewal effect. Treatment areas and delivery methods are personalized in consultation with our medical team.
Follow-Up & Maintenance
Biostimulator results are progressive and develop over weeks to months as your body responds to the treatment. Most biostimulator approaches involve a series of sessions, with maintenance treatments suggested over time to support the result. The exact schedule depends on the treatment chosen, the area treated and individual factors. Our medical team will define a personalized plan with you during your consultation.
Side Effects & Contraindications
As with any medical injectable treatment, biostimulators can cause side effects. Most are mild and temporary, while some less common reactions deserve attention.
- Common side effects: Swelling, redness, tenderness or bruising at the injection site are common in the first few days following treatment. These typically resolve on their own within a few days to a week.
- Less frequent side effects: Small nodules or papules under the skin may develop, sometimes with delayed onset — a recognized consideration with collagen-stimulating injectables, where a post-treatment massage protocol may be recommended to help reduce this risk. Asymmetry, hypersensitivity reactions, infection or pigmentation changes at the injection site can also occur. In rare cases, vascular complications may develop and require immediate medical attention.
- Who should avoid biostimulators: Biostimulator injections are not recommended during pregnancy or breastfeeding, in patients with certain autoimmune conditions, bleeding disorders, active skin infections at the planned injection site, or with a known hypersensitivity to any component of the product.
Frequently Asked Questions
What is the difference between biostimulator injections and dermal fillers?
Dermal fillers, typically based on hyaluronic acid, restore volume immediately by adding product directly under the skin. Biostimulator injections work differently: they stimulate your body to produce new collagen, deliver growth factors from your own blood, or support deep hydration, with results that develop gradually over time. Put simply, a filler adds support from the outside, while a biostimulator prompts the skin to rebuild its own support from within. Dermal fillers act as a temporary scaffold, while biostimulators contribute to longer-term improvements through your own tissue renewal. The two approaches address different goals and can sometimes be combined within a personalized plan.
What are biostimulator injections and how do they work?
Biostimulator injections are treatments designed to support your body's natural production of collagen, growth factor activity or deep hydration over time. Rather than providing immediate volume like dermal fillers, biostimulators trigger a progressive biological response at the injection site. With collagen stimulators, your fibroblasts, the dermal cells that make collagen, are encouraged to build a new support network; with blood-based treatments, it's the platelets' growth factors that restart the natural repair processes. As your body responds to the treatment, new collagen develops gradually or tissue quality improves, contributing to improvements in skin density, structure, texture and hydration. The effect builds over weeks to months and can last several months to over a year, depending on the specific treatment and individual factors.
Can biostimulator injections be combined with other aesthetic treatments?
Yes. Biostimulator injections can be combined with dermal fillers, muscle relaxer injections, energy-based treatments such as fractional lasers, RF microneedling or HIFU (Ultherapy), and medical-grade skincare as part of a personalized plan. Each modality addresses different aspects of skin and facial structure. For example, biostimulators support gradual collagen development in the dermis, while HIFU energy can act on deeper structural layers, creating complementary effects across multiple layers of the skin. Our medical team will assess which combinations are appropriate for your goals, your skin condition and your overall treatment plan.
Why Choose Dermapure
At Dermapure, biostimulators are never a one-off treatment. They are part of the Triangle of Care, our signature approach that brings together injectable treatments, energy-based devices and medical-grade skincare in a plan designed for the long-term health of your skin. Every plan is led by our medical team. And because we are the largest network of medical aesthetic clinics in Canada, our teams share their knowledge and training, so your care benefits from the expertise of the entire network.
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