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Cellular Regeneration through Biostimulation (CRB)

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    Proven Results

    Dermapure relies on a team of highly qualified and experienced physicians whose practice and methods align with our philosophy: achieving a natural look.

    Cellular Regeneration through Biostimulation (CRB) can help stimulate skin cell growth and improve skin texture. Individual responses to treatment can vary. Images provided serve for illustrative purposes only and do not guarantee specific results. 


    Treatment & Technology


    Cellular Regeneration through Biostimulation (CRB) is a treatment that involves centrifuging a small amount of the patient’s blood to isolate the platelet-rich plasma. The resulting serum is then injected directly into the skin using a micro needling technique. This injection process increases the synthesis and regeneration of collagen and elastic fibres and stimulates the growth of skin cells. Cellular Regeneration through Biostimulation (CRB) helps to firm and improve skin texture and reduce the appearance of fine lines and wrinkles, signs of photoaging, enlarged pores, hyperpigmentation, and acne scars.

    Take advantage of this treatment in your clinic

    Treatable Areas

    The face, including the eyelids, neck and décolleté can be treated with Cellular Regeneration through Biostimulation (CRB). It is also used on the scalp to treat alopecia and hair loss.

    What to Expect


    Personalized assessment

    A meeting prior to the Cellular Regeneration through Biostimulation (CRB) treatment allows us to better understand your expectations as well as your skin condition and to build a personalized treatment plan.

    Take pictures

    Pictures taken before the procedure help provide a better view and understanding of the areas affected by the loss of volume and can be used when discussing your goals with the physician. When compared to your “After” pictures, they are an effective way to see the results of the treatment and will be used as a reference over time.

    Blood sampling and plasma extraction

    Collecting a small amount of blood is the first step of the treatment. The blood is then placed in a centrifuge to extract the platelet-rich plasma.

    Clean and disinfect the skin

    Carefully removing all traces of gel, makeup and oil film is an essential step in the microneedling treatment. It is also important to thoroughly disinfect the skin to create an adequate and sterile canvas for the procedure.

    Microneedling injection

    Plasma is then injected directly into the skin using the microneedling technique. The session lasts between 30 and 45 minutes in general.

    Post-treatment procedures

    Post-treatment procedures are applied and post-treatment recommendations carefully explained to ensure optimal recovery and results.

    See if this treatment is right for you.

    Cost of treatment

    The cost varies depending on the area being treated. Contact your clinic for more details!

    *Consultation fee with a physician may apply.

    Follow-up and maintenance

    Depending on the initial state of the skin and the desired results, we can plan approximately 3 sessions with a 2 or 3-week interval.

    It is strongly recommended to combine the Cellular Regeneration through Biostimulation (CRB) treatment with filling injections to maximize the rejuvenating effects. The CRB treatment can also be combined with Microneedling RF treatments to improve the firmness of the skin.


    Pregnant or nursing women should postpone this type of treatment, as should anyone with an autoimmune disease, blood disorder or active skin infection.

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    Frequently Asked Questions

    Are there side effects?

    Following a Cellular Regeneration through Biostimulation (CRB) treatment, you can expect between 12 and 24 hours of redness and a minor edema generally dissipating within a few hours. Makeup can be used on the skin the day following the procedure.

    When can we see results?

    For most patients, results are visible following the first treatment, but full results appear progressively over a few weeks.

    How long will the benefits last? Is maintenance required?

    The reconstructive benefits of the Cellular Regeneration through Biostimulation (CRB) treatment are considered permanent and long-lasting. That being said, this treatment does not stop the internal biological clock and the normal aging of skin. Therefore, an annual or biannual maintenance might be recommended to prevent the effects of time.