One of the latest trends in regenerative skincare is turning heads—not just in South Korea, where it originated, but increasingly across North America as well. Rejuran, a treatment formulated with polydesoxyribonucleotides (PDRN) extracted from salmon DNA, is gaining recognition for its ability to support cellular repair, boost hydration, and improve overall skin quality.
Often referred to as a “skin healer,” Rejuran works with the skin’s natural regeneration processes, making it especially appealing to those looking to enhance texture, elasticity, and long-term skin health—without adding volume.
While this treatment is typically injected in some parts of Asia, it’s important to note that injectable use of PDRN-based products is not authorized in Canada. Instead, in Canada, Rejuran is authorized for topical use only—applied after procedures such as microneedling, RF microneedling, or laser treatments, when the skin barrier is temporarily disrupted and absorption is most effective.
So what exactly is Rejuran, how does it work, and how does it compare to other treatments in the growing field of regenerative aesthetics?
What Is Rejuran and How Can It Benefit Your Skin?
More and more people are turning to regenerative aesthetics, a field focused on stimulating the skin’s natural healing and repair mechanisms rather than simply masking signs of aging. Instead of adding volume or temporarily plumping the skin, regenerative treatments like Rejuran work at a cellular level to restore skin quality, texture, and resilience over time.
Originally developed in South Korea, Rejuran has gained popularity due to its unique ingredient: polydeoxyribonucleotides (PDRN), a form of salmon DNA extract that supports skin regeneration, hydration, and collagen production. But what exactly is PDRN, and how does it help the skin?
What Is PDRN and Why Is Salmon DNA Used in Rejuran?
PDRN (polydeoxyribonucleotide) is a DNA-derived compound that plays a role in cellular repair and regeneration. While it is not naturally present in the skin, it consists of nucleotides—the fundamental building blocks of DNA and RNA, which are essential for tissue growth and healing.
Why Use Salmon DNA?
The idea of using marine-derived DNA in skincare may seem surprising, but research shows that PDRN extracted from salmon sperm has a 96.5% similarity to human DNA. This allows skin cells to recognize and respond to it, helping trigger natural repair mechanisms.
Originally studied for its wound-healing and anti-inflammatory properties, PDRN has been shown to:
- Promote skin regeneration by supporting cell turnover and collagen synthesis
- Enhance hydration by strengthening the skin’s barrier
- Reduce inflammation by modulating cytokine activity, helping calm redness and irritation
Unlike some regenerative ingredients derived from human tissue (such as placenta extracts), salmon DNA is considered a safer and more sustainable alternative. The PDRN used in Rejuran is highly purified, ensuring that only the active, beneficial components are delivered to the skin.
How Does PDRN Work in the Skin?
PDRN acts as a biological messenger, stimulating skin cells to repair and regenerate themselves. It works through three main mechanisms:
- Tissue Repair & Collagen Stimulation – PDRN activates fibroblasts, which boost collagen and elastin production, helping improve skin firmness, elasticity, and the appearance of fine lines.
- Cell Turnover & Skin Renewal – It promotes the shedding of old, damaged skin cells and encourages the formation of new, healthy ones, leading to smoother texture and a more even tone.
- Anti-Inflammatory & Hydration Boosting – PDRN helps reduce redness and irritation, while reinforcing the skin’s moisture barrier, improving overall skin health and resilience.
To achieve these results, however, the product must penetrate beyond the surface of the skin. In countries like South Korea, Rejuran is commonly administered through intradermal injections. But in Canada, this injectable use is not authorized. At Dermapure, Rejuran is used exclusively as a topical solution, applied immediately after procedures that temporarily disrupt the skin barrier—such as microneedling, RF microneedling, or laser treatments. These microchannels enhance the absorption of active ingredients, allowing the PDRN to reach deeper layers of the skin while ensuring compliance with Health Canada regulations.
A Regenerative Alternative: Discover VAMP
For those seeking to enhance post-treatment skin recovery, VAMP offers a revitalizing solution that aligns with the principles of regenerative aesthetics. Designed to be applied topically after procedures like microneedling, RF microneedling, or laser treatments, VAMP delivers a rich blend of active ingredients that nourish the skin and support visible repair.
Its formula combines polydeoxyribonucleotides (PDRN) with hyaluronic acid and four key amino acids, including glycine and proline—two major building blocks of collagen. These components work synergistically to improve hydration, support collagen and elastin production, and strengthen the skin’s barrier function.
By helping the skin recover more effectively after controlled micro-injury, VAMP contributes to a smoother, more radiant complexion. Whether used on its own or alongside other regenerative approaches, it offers a nutrient-dense boost tailored to support the skin’s natural healing process.
Beyond PDRN Salmon DNA Facial – Treatments That Support Your Skin from Within
f you’re looking to improve skin quality, boost collagen, and restore a youthful glow—without adding volume—regenerative treatments offer a natural way to enhance your skin from within. While Rejuran Microneedling has gained attention for its skin-repairing properties, it is just one of many innovative regenerative options available today.
In Canada and the U.S., several Health Canada- and FDA-approved treatments work with your body’s natural processes to stimulate collagen production, accelerate skin renewal, and strengthen the skin barrier. From biostimulating injectables and PRP/PRF to exosome therapy and advanced laser treatments, regenerative aesthetics is redefining how we care for our skin, helping to improve texture, elasticity, and overall skin health over time.
Exosome Therapy
Exosomes are small extracellular vesicles naturally produced by cells to transmit biological signals and regulate cellular communication. They play a key role in tissue repair, collagen production, and skin regeneration. However, as we age, this regenerative activity slows down, leading to loss of elasticity, hydration, and overall skin vitality.
In aesthetic medicine, exosomes used in treatments are purified from stem cell sources and applied topically after treatments that create microchannels, such as:
- Microneedling – Enhances absorption and stimulates skin renewal
- Clear + Brilliant laser – Supports tissue repair and improves skin tone
- PRP (Platelet-Rich Plasma) therapy – Works synergistically to accelerate skin healing
Because exosomes are naturally occurring messengers, they do not harm or thin the skin. Instead, they work with the body’s own processes to enhance recovery, reduce inflammation, and improve long-term skin health.
Biostimulating Injectables: Enhancing Skin Quality from Within
Unlike traditional fillers, biostimulating injectables don’t just add volume, they work by stimulating the skin’s natural collagen production and improving hydration, leading to firmer, more radiant skin over time. These treatments help restore skin density, elasticity, and hydration, making them a key part of regenerative aesthetics.
Collagen-Stimulating Injectables
As collagen production slows with age, the skin becomes thinner, less elastic, and more prone to wrinkles. Collagen stimulators—such as Sculptra (poly-L-lactic acid) and Radiesse (calcium-based microspheres)—work by activating fibroblasts, the cells responsible for producing collagen and elastin. Over time, they restore skin density, improve firmness, and reduce sagging, making them ideal for gradual, natural-looking rejuvenation.
Skin Boosters
For skin that lacks moisture, radiance, or elasticity, hyaluronic acid-based skin boosters, like SkinVive or Redensity 1, deliver intense hydration directly into the skin’s deeper layers. Unlike traditional fillers, they don’t add volume but enhance water retention, improve skin texture, and create a lasting glow. By reinforcing the skin barrier and increasing cellular hydration, they help skin appear plumper, smoother, and more refreshed over time.
By stimulating collagen renewal and optimizing skin hydration from within, biostimulating injectables offer a long-term approach to healthier, firmer, and more youthful-looking skin without altering facial volume.
PRP (Platelet-Rich Plasma) & PRF (Platelet-Rich Fibrin)
PRP and PRF are regenerative treatments derived from your own blood, designed to stimulate collagen production, accelerate skin healing, and improve overall skin quality. These treatments work by isolating platelets and growth factors, which are then reintroduced into the skin to trigger natural repair and rejuvenation.
- PRP (Platelet-Rich Plasma) – A concentrated form of platelets and growth factors that stimulate collagen, improve skin texture, and enhance radiance.
- PRF (Platelet-Rich Fibrin) – A more advanced version of PRP, containing higher levels of growth factors and fibrin, which help promote longer-lasting regeneration and volume restoration.
Both treatments are highly effective for dull skin, fine lines, acne scars, and even hair restoration, offering a natural way to enhance skin health over time.
Laser & Energy-Based Skin Regeneration: Stimulating Repair from Within
Fractional laser treatments deliver precise energy into the skin, creating controlled micro-injuries that trigger the body’s natural healing response. As the skin repairs itself, collagen and elastin production increases, helping to improve firmness, smooth texture, and reduce the appearance of scars and pigmentation.
These treatments are particularly effective for softening fine lines, refining pores, and evening out skin tone. By working within the skin’s deeper layers, they stimulate long-term structural improvements, leading to a stronger, more resilient, and naturally rejuvenated complexion.
Finding the Right Approach for Your Skin
Regenerative aesthetics offer a range of solutions to restore skin quality, boost collagen, and enhance hydration, but the right treatment depends on your individual needs. Some people benefit from collagen stimulators to improve firmness and elasticity, while others may see better results with skin boosters for deep hydration or exosome and PRP/PRF therapies to accelerate skin healing and renewal.
The best way to determine what’s right for you is through a personalized consultation. A skincare specialist can assess your skin concerns, discuss your goals, and create a customized treatment plan that aligns with your needs. Whether you’re looking to address fine lines, loss of elasticity, uneven texture, or overall skin vitality, expert guidance can help you achieve natural, long-lasting results.
Book a consultation today to explore the best regenerative treatments for your skin.
